Conquering the Challenges of the Nazarov Cyclization
نویسندگان
چکیده
One of the most powerful synthetic transformations with the ability to stereospecifically create new carbon-carbon bonds by simple orbital reorganization are electrocyclic reactions. One of the most recognized electrocyclic reactions is known as Nazarov cyclization. This reaction involves the conversion of divinyl ketones to cyclopentenones by activation with a Brønsted or Lewis acid. It was originally discovered by Ivan Nikolaevich Nazarov (1906-1957) in 1942 while studying the rearrangements of vinyl ethinyl carbinols and allyl vinyl ketones (Scheme 1).
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